Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20105793 | 0.94 | MDM2 (0.61) | MDM2 | |
| SCHEMBL20106135 | 0.92 | MDM2 (0.60) | MDM2TP53 | |
| SCHEMBL20105905 | 0.90 | MDM2 (0.58) | MDM2 | |
| SCHEMBL20106489 | 0.85 | MDM2 (0.63) | MDM2 | |
| SCHEMBL20106428 | 0.84 | MDM2 (0.66) | MDM2TP53 | |
| SCHEMBL20106399 | 0.83 | MDM2 (0.57) | MDM2 | |
| SCHEMBL20106117 | 0.83 | MDM2 (0.60) | MDM2 | |
| SCHEMBL20106488 | 0.83 | MDM2 (0.61) | MDM2 | |
| SCHEMBL20106322 | 0.82 | MDM2 (0.49) | MDM2 | |
| SCHEMBL20105907 | 0.82 | MDM2 (0.67) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |