SCHEMBL20106185

SCHEMBL20106185

Cc1cnn2ccc(N3CCCC3c3cc(F)cnc3CCCN)nc12

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 20/20 0.61
JAK2 O60674 15/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20106047 0.88 NTRK1 (0.59) NTRK1JAK2
SCHEMBL20106142 0.88 NTRK1 (0.59) NTRK1JAK2
SCHEMBL2599206 0.87 NTRK1 (0.72) NTRK1JAK2
SCHEMBL2599208 0.87 NTRK1 (0.72) NTRK1JAK2
SCHEMBL20613723 0.87 NTRK1 (0.58) NTRK1JAK2
Hydrochloric Acid SCHEMBL2599196 0.86 NTRK1 (0.71) NTRK1JAK2
SCHEMBL20624723 0.86 NTRK1 (0.66) NTRK1JAK2
SCHEMBL22198099 0.86 NTRK1 (0.66) NTRK1JAK2
SCHEMBL23408760 0.81 NTRK1 (0.74) NTRK1JAK2
SCHEMBL20015988 0.81 NTRK1 (0.74) NTRK1JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019005796-A1 PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF ZHAO QIAN (US) 2019-01-03 WO disclosed
WO-2018081417-A2 PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF ZHAO QIAN (US) 2018-05-03 WO disclosed