Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20106139 | 0.97 | MDM2 (0.76) | MDM2 | |
| SCHEMBL20105821 | 0.91 | MDM2 (0.68) | MDM2 | |
| SCHEMBL20106113 | 0.90 | MDM2 (0.82) | MDM2 | |
| SCHEMBL17314030 | 0.89 | MDM2 (1.00) | MDM2 | |
| SCHEMBL15931081 | 0.89 | MDM2 (1.00) | MDM2 | |
| SCHEMBL20105712 | 0.89 | MDM2 (0.84) | MDM2 | |
| SCHEMBL20106119 | 0.88 | MDM2 (0.65) | MDM2 | |
| SCHEMBL20106392 | 0.88 | MDM2 (0.65) | MDM2 | |
| SCHEMBL20106361 | 0.88 | MDM2 (0.67) | MDM2 | |
| SCHEMBL20105676 | 0.87 | MDM2 (0.66) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |