Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18185851 | 0.80 | MAPK8 (0.43) | CHEK1KCNH2MAP4K1USP8MAPK8 | |
| SCHEMBL17123788 | 0.77 | USP8 (0.40) | MAP4K1USP8 | |
| SCHEMBL20903906 | 0.77 | CHEK1 (0.33) | CHEK1KCNH2MAP4K1 | |
| SCHEMBL10220596 | 0.75 | CHEK1 (0.43) | CHEK1KCNH2MAP4K1CHEK2 | |
| SCHEMBL20095136 | 0.75 | USP8 (0.39) | MAP4K1USP8 | |
| SCHEMBL620504 | 0.75 | USP8 (0.42) | MAP4K1USP8MAPK8MAPK9 | |
| SCHEMBL617396 | 0.74 | CHEK1 (0.44) | CHEK1KCNH2MAP4K1CHEK2 | |
| SCHEMBL14861758 | 0.74 | SYK (0.47) | CHEK1KCNH2MAP4K1MAPK8MAPK9 | |
| SCHEMBL30140908 | 0.74 | SYK (0.47) | CHEK1KCNH2MAP4K1MAPK8MAPK9 | |
| SCHEMBL14679287 | 0.72 | CHEK1 (0.42) | CHEK1KCNH2MAP4K1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532064-B1 | COMBINATION TREATMENTS COMPRISING IMIDAZOPYRAZINONES FOR THE TREATMENT OF PSYCHIATRIC AND/OR COGNITIVE DISORDERS | H LUNDBECK AS (DK) | 2020-07-29 | — | — | EP | disclosed |
| WO-2018078038-A1 | COMBINATION TREATMENTS COMPRISING IMIDAZOPYRAZINONES FOR THE TREATMENT OF PSYCHIATRIC AND/OR COGNITIVE DISORDERS | H. LUNDBECK A/S (DK) | 2018-05-03 | — | — | WO | disclosed |
| WO-2018078042-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF IMIDAZOPYRAZINONES | H. LUNDBECK A/S (DK) | 2018-05-03 | — | — | WO | disclosed |