Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088518 | 0.89 | PDE4D (0.31) | PDE4D | |
| SCHEMBL20088499 | 0.78 | PDE10A (0.38) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| SCHEMBL20088505 | 0.75 | PDE4D (0.33) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| SCHEMBL20106861 | 0.74 | PDE10A (0.31) | PDE10A | |
| SCHEMBL20094342 | 0.74 | XPO1 (0.35) | PDE4D | |
| SCHEMBL20088556 | 0.69 | HRH4 (0.34) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| SCHEMBL20088601 | 0.66 | ADORA2A (0.37) | — | |
| SCHEMBL20088551 | 0.66 | PDE4A (0.36) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20088517 | 0.64 | PDE10A (0.32) | PDE10A | |
| SCHEMBL25340830 | 0.62 | HRH4 (0.37) | PDE4DPDE4APDE4BPDE4CPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018080917-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |