Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20395949 | 0.85 | EPHX2 (0.48) | EPHX1GPR119EPHX2NAMPTHPGD | |
| SCHEMBL20106807 | 0.85 | EHMT2 (0.44) | EPHX1EPHX2HPGDUSP2SMN1; SMN2 | |
| SCHEMBL743999 | 0.83 | EPHX1 (0.65) | EPHX1GPR119EPHX2HPGDUSP2 | |
| SCHEMBL20733922 | 0.83 | EPHX1 (0.48) | EPHX1GPR119EPHX2NAMPTHPGD | |
| SCHEMBL22305158 | 0.80 | USP2 (0.49) | EPHX1GPR119EPHX2NAMPTHPGD | |
| SCHEMBL1474868 | 0.80 | USP2 (0.49) | EPHX1GPR119EPHX2NAMPTHPGD | |
| SCHEMBL24811332 | 0.80 | EPHX1 (0.43) | EPHX1EPHX2HPGDUSP2SMN1; SMN2 | |
| SCHEMBL29589460 | 0.80 | EPHX1 (0.51) | EPHX1EPHX2HPGDUSP2SMN1; SMN2 | |
| SCHEMBL29589383 | 0.80 | EPHX1 (0.48) | EPHX1EPHX2HPGDUSP2SMN1; SMN2 | |
| SCHEMBL16969327 | 0.79 | USP2 (0.47) | EPHX1GPR119EPHX2NAMPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532459-B1 | LSD1 INHIBITORS AND MEDICAL USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018081343-A1 | LSD1 INHIBITORS AND MEDICAL USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |