Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20106767 | 0.97 | TLR7 (0.55) | TLR7TLR8NUDT1 | |
| SCHEMBL20106966 | 0.92 | TLR7 (0.54) | TLR7TLR8NUDT1 | |
| SCHEMBL20106823 | 0.90 | TLR7 (0.60) | TLR7NUDT1 | |
| SCHEMBL18207821 | 0.89 | TLR7 (0.61) | TLR7TLR8 | |
| SCHEMBL20106981 | 0.88 | TLR7 (0.56) | TLR7TLR8NUDT1 | |
| SCHEMBL20106769 | 0.88 | TLR7 (0.52) | TLR7TLR8NUDT1 | |
| SCHEMBL18207477 | 0.85 | TLR7 (0.62) | TLR7TLR8 | |
| SCHEMBL29488807 | 0.85 | TLR7 (0.62) | TLR7TLR8 | |
| SCHEMBL18207273 | 0.85 | TLR7 (0.63) | TLR7NUDT1 | |
| SCHEMBL18207528 | 0.83 | TLR7 (0.63) | TLR7TLR8NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078149-A1 | NOVEL CYCLICSULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-03 | — | — | WO | disclosed |