SCHEMBL20108161

SCHEMBL20108161

C[C@@H](Oc1cc(-c2cnc3cc(-c4cnn(CCN(C)C)c4)ccn23)sc1C(N)=O)c1ccccc1C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NEK2 P51955 11/20 1.00
FLT3 P36888 2/20 1.00
PLK1 P53350 9/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2C9 P11712 2/20 0.55
PLK3 Q9H4B4 1/20 0.54
AURKA O14965 2/20 0.54
CHEK1 O14757 1/20 0.51
ABL1 P00519 1/20 0.51
CDK4 P11802 1/20 0.51
CDK2 P24941 1/20 0.51
AKT1 P31749 1/20 0.51
PIK3CA P42336 1/20 0.51
GSK3B P49841 1/20 0.51
DYRK1A Q13627 1/20 0.51
RPS6KA1 Q15418 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20108040 1.00 NEK2 (1.00) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108291 1.00 NEK2 (1.00) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108038 0.95 NEK2 (0.90) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108258 0.95 NEK2 (0.90) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108037 0.93 NEK2 (0.87) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108041 0.93 NEK2 (0.87) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108284 0.93 NEK2 (0.87) NEK2FLT3PLK1CYP3A4CYP2C9
SCHEMBL20108155 0.88 NEK2 (0.79) NEK2FLT3PLK1PLK3AURKA
SCHEMBL2523731 0.81 PLK1 (0.77) NEK2FLT3PLK1PLK3
SCHEMBL2519716 0.75 PLK1 (0.65) NEK2FLT3PLK1PLK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121749774-B LLC resonant converter switching control method, controller, system and medium 中国电子科技集团公司第四十三研究所 2026-05-15 CN claimed
CN-121749774-B LLC resonant converter switching control method, controller, system and medium 中国电子科技集团公司第四十三研究所 2026-05-15 CN disclosed
CN-115085558-B DAB output serial voltage balancer voltage equalizing control method and system 湖南大学 2025-04-22 CN disclosed
US-20240355686-A1 Clinical Methods and Pharmaceutical Compositions Employing AMPA Receptor Antagonists to Treat Glioblastoma and Other Cancers RADIN DANIEL PIERCE (US) 2024-10-24 US disclosed
CN-115995981-B DAB converter inductance current direct current bias eliminating method and control system 浙江巨磁智能技术有限公司 2024-06-07 CN disclosed
CN-117424453-A DAB power oscillation control method and system applied to energy storage self-heating system 湖南大学 2024-01-19 CN disclosed
CN-115995981-A DAB converter inductance current direct current bias eliminating method and control system 浙江巨磁智能技术有限公司 2023-04-21 CN disclosed
CN-115085558-A DAB output series voltage balancer voltage-sharing control method and system 湖南大学 2022-09-20 CN disclosed
WO-2018081719-A1 SMALL MOLECULE INHIBITORS OF NEK2 AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2018-05-03 WO disclosed