Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.63 |
| ▸ | NEK2 | P51955 | 4/20 | 0.61 |
| ▸ | CSF1R | P07333 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.61 |
| ▸ | STK3 | Q13188 | 3/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.61 |
| ▸ | BRSK1 | Q8TDC3 | 3/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.61 |
| ▸ | PIM1 | P11309 | 2/20 | 0.61 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.61 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29915268 | 0.79 | MAOB (0.57) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL3923132 | 0.76 | PLK1 (0.78) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL3933141 | 0.76 | PLK1 (0.78) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL4551324 | 0.76 | PLK1 (1.00) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL28939142 | 0.76 | MAOB (0.63) | PLK1NEK2CSF1RKDRLIMK1 | |
| Gw843682X SCHEMBL29432471 | 0.75 | PLK1 (1.00) | PLK1NEK2CSF1RKDRLIMK1 | |
| Gw843682X SCHEMBL31416068 | 0.75 | PLK1 (1.00) | PLK1NEK2CSF1RKDRLIMK1 | |
| Gw843682X SCHEMBL1286884 | 0.75 | PLK1 (1.00) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL5062438 | 0.75 | PLK1 (0.58) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL2516541 | 0.75 | PLK1 (1.00) | PLK1NEK2CSF1RKDRLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081719-A1 | SMALL MOLECULE INHIBITORS OF NEK2 AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2018-05-03 | — | — | WO | disclosed |