⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497205 | 0.74 | — | — | |
| SCHEMBL20578549 | 0.74 | KCNH2 (0.40) | — | |
| SCHEMBL9998552 | 0.74 | — | — | |
| SCHEMBL31504928 | 0.72 | HAO1 (0.49) | — | |
| Hydrochloric Acid SCHEMBL2450441 | 0.72 | — | — | |
| SCHEMBL20409158 | 0.70 | — | — | |
| SCHEMBL8309544 | 0.69 | — | — | |
| SCHEMBL461868 | 0.67 | KCNH2 (0.39) | — | |
| SCHEMBL527210 | 0.67 | APP (0.52) | — | |
| SCHEMBL19303487 | 0.66 | KCNH2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558980-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING (IT) | 2021-01-27 | — | — | EP | claimed |
| EP-3749666-A1 | HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2020-12-16 | — | — | EP | claimed |
| US-20200383984-A1 | HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2020-12-10 | — | — | US | claimed |
| CN-111971280-A | Heteroaryl compounds, pharmaceutical compositions thereof and therapeutic uses thereof | 耶路撒冷希伯来大学伊萨姆研究发展公司 | 2020-11-20 | — | — | CN | claimed |
| US-10815222-B2 | Compounds for use in the treatment of kinetoplastid infection | C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING (IT) | 2020-10-27 | — | — | US | claimed |
| US-20200095232-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING (IT) | 2020-03-26 | — | — | US | claimed |
| EP-3558980-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening (IT) | 2019-10-30 | — | — | EP | claimed |
| WO-2019155468-A1 | HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2019-08-15 | — | — | WO | claimed |
| CN-110087466-A | ACTIVE COMPOUND COMBINATIONS | 拜耳作物科学股份公司 | 2019-08-02 | — | — | CN | claimed |
| CN-110072390-A | Use the method for carboxamides derivatives prevention and treatment bacterial diseases of plants | 拜耳作物科学股份公司 | 2019-07-30 | — | — | CN | claimed |
| CN-105593214-B | Method for synthesizing N-benzyl-N-cyclopropyl-1H-pyrazole-4-formamide derivative | 拜耳作物科学股份公司 | 2018-05-29 | — | — | CN | claimed |
| CN-106962403-A | Include biocontrol agent and insecticide composition | 拜耳作物科学股份公司 | 2017-07-21 | — | — | CN | claimed |
| CN-104363758-B | Compositions comprising biological control agents and pesticides | 拜耳作物科学公司 | 2017-02-08 | — | — | CN | claimed |
| EP-2086944-A1 | PROCESS FOR PREPARING DIFLUOROMETHYLPYRAZOLYL CARBOXYLATES | BASF SE (DE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008053043-A1 | PROCESS FOR PREPARING DIFLUOROMETHYLPYRAZOLYL CARBOXYLATES | BASF SE (DE) | 2008-05-08 | — | — | WO | claimed |
| US-6967197-B2 | Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-22 | — | — | US | claimed |
| US-20030134849-A1 | Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | US | claimed |
| WO-2003018019-A2 | NEW USE OF CYCLIC COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-06 | — | — | WO | claimed |
| EP-1259499-A1 | THIAZEPINYL HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-27 | — | — | EP | claimed |
| WO-2001060808-A1 | THIAZEPINYL HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-08-23 | — | — | WO | claimed |