Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 9/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.39 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.39 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.39 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636606 | 0.92 | KRAS (0.53) | KRASSMARCA2SMARCA4PBRM1CNR1 | |
| SCHEMBL29765860 | 0.92 | KRAS (0.53) | KRASSMARCA2SMARCA4PBRM1CNR1 | |
| SCHEMBL20109704 | 0.86 | KRAS (0.56) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL17030876 | 0.83 | SMARCA2 (0.43) | KRASSMARCA2SMARCA4PBRM1GRIA1 | |
| SCHEMBL18128438 | 0.82 | KRAS (0.45) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL20858007 | 0.81 | TLR9 (0.41) | SMARCA2SMARCA4PBRM1CNR1CNR2 | |
| SCHEMBL29765694 | 0.80 | KCNH2 (0.40) | SMARCA2SMARCA4PBRM1CNR1CNR2 | |
| SCHEMBL16637457 | 0.80 | KCNH2 (0.40) | SMARCA2SMARCA4PBRM1CNR1CNR2 | |
| SCHEMBL16636866 | 0.80 | KRAS (0.55) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21458461 | 0.78 | KRAS (0.51) | KRASCNR1CNR2CRBNGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370386-B2 | Substituted quinolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2018-05-03 | — | — | US | disclosed |
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | KRAS 1/4885SMARCA2 1445/4885SMARCA4 1871/4885 |
| US-10370386-B2 | Substituted quinolines as inhibitors of KRAS G12C | KRAS, NRAS, HRAS | KRAS 1/4885SMARCA2 1359/4885SMARCA4 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.