Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 7/20 | 0.70 |
| ▸ | CACNG8 | Q8WXS5 | 7/20 | 0.70 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189597 | 0.95 | GRIA1 (0.73) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189353 | 0.93 | GRIA1 (0.63) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189444 | 0.88 | GRIA1 (0.58) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189391 | 0.84 | GRIA1 (0.60) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL20111134 | 0.83 | GRIA1 (0.62) | GRIA1CACNG8CACNG2CYP1A2CYP11B1 | |
| SCHEMBL18189313 | 0.83 | GRIA1 (1.00) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189485 | 0.83 | GRIA1 (1.00) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL20111132 | 0.82 | GRIA1 (0.58) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189600 | 0.82 | GRIA1 (0.57) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189528 | 0.80 | GRIA1 (0.69) | GRIA1CACNG8CACNG2AHRTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604484-B2 | Indolone compounds and their use as AMPA receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-31 | — | — | US | disclosed |
| US-20180118683-A1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | US | disclosed |
| US-20180118683-A1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604484-B2 | Indolone compounds and their use as AMPA receptor modulators | GRIN3A, GRIN1, GRIN2B | GRIA1 23/4885CACNG8 317/4885CACNG2 370/4885 |
| US-20180118683-A1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | GRIN3A, GRIN1, GRIN2B | GRIA1 23/4885CACNG8 317/4885CACNG2 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.