Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 10/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17970547 | 0.83 | AKR1C3 (0.41) | NR4A2GAANOTUMKDM4E | |
| SCHEMBL21419429 | 0.82 | NR4A2 (0.55) | NR4A2CREBBPCHEK1 | |
| SCHEMBL24330121 | 0.81 | NR4A2 (0.48) | NR4A2CREBBPCHEK1MAPTALDH1A1 | |
| SCHEMBL23305035 | 0.80 | NR4A2 (0.47) | NR4A2CREBBPCHEK1MAPTALDH1A1 | |
| SCHEMBL17065792 | 0.77 | NR4A2 (0.44) | NR4A2CREBBPCHEK1MAPTALDH1A1 | |
| SCHEMBL28795512 | 0.75 | NR4A2 (0.38) | NR4A2CREBBPGABRA1GABRB1GABRA3 | |
| SCHEMBL1223596 | 0.75 | NR4A2 (0.61) | NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL29886596 | 0.75 | NR4A2 (0.61) | NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL1229320 | 0.72 | KDM4E (0.43) | NR4A2MAPTALDH1A1GAANOTUM | |
| SCHEMBL1636595 | 0.72 | KDM4E (0.43) | NR4A2MAPTALDH1A1GAANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116947856-A | EZH2 inhibitor and preparation method and application thereof | 星希尔生物科技(上海)有限公司 | 2023-10-27 | — | — | CN | disclosed |
| WO-2018081530-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-05-03 | — | — | WO | disclosed |