Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979376 | 0.93 | MEN1 (0.47) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL10684102 | 0.78 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL9852204 | 0.74 | MEN1 (0.60) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL4126086 | 0.74 | MEN1 (0.60) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL18179825 | 0.74 | MEN1 (0.60) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL5255332 | 0.73 | KMT2A (0.45) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL31637724 | 0.73 | CA12 (0.49) | ALDH1A1CA12HPGD | |
| SCHEMBL4195648 | 0.73 | MEN1 (0.53) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL18359536 | 0.73 | MEN1 (0.53) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL10678544 | 0.72 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |