SCHEMBL20113375

SCHEMBL20113375

CCCCC(=O)Nc1ccc(C#N)c(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AR P10275 6/20 0.59
RORC P51449 1/20 0.52
TSHR P16473 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28647119 0.92 AR (0.61) ARRORC
SCHEMBL20852437 0.87 AR (0.62) ARRORC
SCHEMBL29504198 0.86 AR (0.62) AR
SCHEMBL19695360 0.86 AR (0.62) AR
SCHEMBL3091589 0.85 AR (0.61) AR
SCHEMBL2132362 0.85 AR (0.61) AR
SCHEMBL13697823 0.84 AR (0.47) ARRORC
SCHEMBL3289165 0.84 AR (0.58) ARRORC
SCHEMBL3289077 0.83 AR (0.55) ARRORC
SCHEMBL1773545 0.82 AR (0.62) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10300037-B2 SARMs and method of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2019-05-28 US disclosed
US-20180116994-A1 SARMS AND METHOD OF USE THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2018-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10300037-B2 SARMs and method of use thereof SARM1, CPT1B, TNNI3 AR 2582/4885RORC 4525/4885TSHR 4605/4885
US-20180116994-A1 SARMS AND METHOD OF USE THEREOF SARM1, CPT1B, TNNI3 AR 2582/4885RORC 4525/4885TSHR 4605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.