Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113812 | 0.91 | TP53 (0.57) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113814 | 0.91 | TP53 (0.73) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113800 | 0.89 | TP53 (0.56) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113831 | 0.89 | TP53 (0.56) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113811 | 0.89 | TP53 (0.64) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113816 | 0.89 | MAPT (0.57) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113806 | 0.88 | TP53 (0.59) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20113803 | 0.87 | TP53 (0.53) | TP53MAPTPOLBLMNATDP1 | |
| SCHEMBL20114214 | 0.85 | MAPT (0.54) | TP53MAPTPOLBLMNAFYN | |
| SCHEMBL20114216 | 0.84 | TP53 (0.59) | TP53MAPTPOLBLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190256474-A1 | N-PHENYL-2-(3-PHENYL-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)ACETAMIDE DERIVATIVES FOR TREATING CYSTIC FIBROSIS | PROTEOSTASIS THERAPEUTICS, INC. | 2019-08-22 | — | — | US | disclosed |
| US-20190256474-A1 | N-PHENYL-2-(3-PHENYL-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)ACETAMIDE DERIVATIVES FOR TREATING CYSTIC FIBROSIS | PROTEOSTASIS THERAPEUTICS, INC. | 2019-08-22 | — | — | US | disclosed |
| WO-2018081377-A1 | N-PHENYL-2-(3-PHENYL-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)ACETAMIDE DERIVATIVES FOR TREATING CYSTIC FIBROSIS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256474-A1 | N-PHENYL-2-(3-PHENYL-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)ACETAMIDE DERIVATIVES FOR TREATING CYSTIC FIBROSIS | CFTR, PKD2, CLCN2 | TP53 2421/4885MAPT 4874/4885POLB 3064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.