Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 1.00 |
| ▸ | SCN9A | Q15858 | 11/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 11/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30479360 | 1.00 | CYP3A4 (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115629 | 0.95 | CYP3A4 (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL30479359 | 0.95 | CYP3A4 (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115551 | 0.91 | CYP3A4 (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL29013645 | 0.90 | SCN5A (0.82) | CYP3A4SCN9ASCN5A | |
| SCHEMBL30479345 | 0.90 | SCN9A (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115766 | 0.90 | SCN9A (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115714 | 0.89 | SCN5A (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL21680266 | 0.89 | SCN5A (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115720 | 0.89 | SCN5A (1.00) | CYP3A4SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110088093-B | Acyl sulfonamide nav1.7 inhibitors | 百时美施贵宝公司 | 2023-06-13 | — | — | CN | disclosed |
| EP-3532462-B1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| US-10836758-B2 | Acyl sulfonamide NaV1.7 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-11-17 | — | — | US | disclosed |
| US-20200048240-A1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018081384-A1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836758-B2 | Acyl sulfonamide NaV1.7 inhibitors | SCN7A, SCN1A, SCN8A | CYP3A4 2112/4885SCN9A 9/4885SCN5A 7/4885 |
| US-20200048240-A1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | SCN7A, SCN1A, SCN8A | CYP3A4 2112/4885SCN9A 9/4885SCN5A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.