Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.68 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.68 |
| ▸ | SCN5A | Q14524 | 12/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20115725 | 0.86 | SCN5A (0.66) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115772 | 0.85 | SCN5A (0.67) | CYP3A4SCN9ASCN5A | |
| SCHEMBL23913168 | 0.85 | SCN5A (0.67) | CYP3A4SCN9ASCN5A | |
| SCHEMBL30479371 | 0.81 | CYP3A4 (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115718 | 0.81 | CYP3A4 (1.00) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115721 | 0.81 | SCN5A (0.65) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115783 | 0.79 | SCN5A (0.64) | CYP3A4SCN9ASCN5A | |
| SCHEMBL23913156 | 0.79 | SCN9A (0.67) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115781 | 0.79 | SCN5A (0.66) | CYP3A4SCN9ASCN5A | |
| SCHEMBL20115636 | 0.79 | SCN5A (0.65) | CYP3A4SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532462-B1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018081384-A1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-03 | — | — | WO | disclosed |