Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.67 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26373753 | 0.82 | ADORA2A (0.49) | ADORA2AADORA2BKMOESR1LMNA | |
| SCHEMBL16158006 | 0.82 | ADORA2A (0.49) | ADORA2AADORA2BESR1LMNAKDM4C | |
| SCHEMBL14910374 | 0.82 | ADORA2A (0.62) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL18853871 | 0.82 | ESR1 (0.63) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL17232702 | 0.82 | ADORA2A (0.62) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL2144945 | 0.82 | ADORA2A (0.62) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL14752235 | 0.82 | ADORA2A (0.62) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL26373686 | 0.80 | ADORA2A (0.59) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL26997295 | 0.80 | ADORA2A (0.59) | ADORA2AADORA2BKMOESR1SLC22A12 | |
| SCHEMBL14752738 | 0.78 | ADORA2A (0.46) | ADORA2AADORA2BKMOSLC22A12GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |