Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770370 | 0.84 | TP53 (0.50) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL1491464 | 0.83 | TSHR (0.61) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL29502076 | 0.82 | CYP3A4 (0.69) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL30451644 | 0.82 | CYP3A4 (0.69) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL3791936 | 0.82 | CYP3A4 (0.69) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL7747989 | 0.82 | CYP3A4 (0.69) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL8254027 | 0.82 | TSHR (0.64) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL8771433 | 0.80 | CYP3A4 (0.67) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL6756802 | 0.80 | TSHR (0.72) | CYP3A4TP53MAOBTSHRALDH1A1 | |
| SCHEMBL29437009 | 0.80 | TSHR (0.79) | CYP3A4TP53MAOBTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105330584-A | Method for preparing 4-methoxyindoline | CHANGZHOU INST ENG TECH | 2016-02-17 | — | — | CN | claimed |
| CN-103958500-B | Kinases inhibitor | ORION CORP. (FI) | 2016-04-27 | — | — | CN | disclosed |
| CN-105518005-A | Tricyclic pyridine-carboxamide derivatives as ROCK inhibitors | BRISTOL MYERS SQUIBB CO | 2016-04-20 | — | — | CN | disclosed |
| CN-105517993-A | Aryl amide kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2016-04-20 | — | — | CN | disclosed |
| CN-103492377-B | As the triazolopyridine compounds of PIM kinase inhibitor | ARRAY BIOPHARMA INC. (US) | 2016-04-20 | — | — | CN | disclosed |
| CN-103827090-B | Substituted quinolines and their use as pharmaceuticals | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-04-20 | — | — | CN | disclosed |
| CN-105492444-A | Tricyclic pyridine-carboxamide derivatives as ROCK inhibitors | BRISTOL MYERS SQUIBB CO | 2016-04-13 | — | — | CN | disclosed |
| CN-103189373-B | The Triazolopyridine replaced | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-06 | — | — | CN | disclosed |
| CN-101501061-B | As the macrocylc compound of antiviral | MSD ITALIA S.R.L. (IT) | 2016-03-09 | — | — | CN | disclosed |
| CN-105367583-A | THIENO[2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | UNIV LEUVEN KATH | 2016-03-02 | — | — | CN | disclosed |
| CN-103827090-A | Substituted quinolines and their use as pharmaceuticals | BOEHRINGER INGELHEIM INT | 2014-05-28 | — | — | CN | disclosed |
| CN-103649097-A | Novel cephalosporins used as antibacterial agents | ZOETIS LLC | 2014-03-19 | — | — | CN | disclosed |
| CN-103626749-A | Substituted oxazolidinone compound, and pharmaceutical composition containing compound and application thereof | SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD | 2014-03-12 | — | — | CN | disclosed |
| CN-103547570-A | Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists | JANSSEN PHARMACEUTICA NV | 2014-01-29 | — | — | CN | disclosed |
| CN-103492377-A | Triazolopyridine compounds as PIM kinase inhibitors | ARRAY BIOPHARMA INC | 2014-01-01 | — | — | CN | disclosed |
| CN-103209960-A | Sulfonamide compounds useful as CYP17 inhibitors | BRISTOL MYERS SQUIBB CO | 2013-07-17 | — | — | CN | disclosed |
| CN-103189373-A | Substituted triazolopyridines | BAYER IP GMBH | 2013-07-03 | — | — | CN | disclosed |
| CN-102985422-A | Pyrrolopyridine and pyrrolopyrimidine inhibitors of kinases | ABBVIE INC | 2013-03-20 | — | — | CN | disclosed |
| EP-2509954-A1 | 4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072241-A1 | 4 -OXO- IH -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | WO | disclosed |