Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116054 | 0.84 | USP30 (0.37) | MAPTKDM4EALDH1A1USP30PIK3CD | |
| SCHEMBL20117183 | 0.84 | MAPT (0.40) | MAPTKDM4EALDH1A1PIK3CDPTGER3 | |
| SCHEMBL20116454 | 0.83 | S1PR1 (0.43) | ALDH1A1HDAC8S1PR1HDAC4 | |
| SCHEMBL20116504 | 0.82 | HDAC8 (0.39) | MAPTL3MBTL1HDAC8PTGER3S1PR1 | |
| SCHEMBL20116238 | 0.81 | S1PR1 (0.38) | KDM4EALDH1A1HDAC8USP30TBK1 | |
| SCHEMBL20116242 | 0.81 | PIK3CD (0.34) | HDAC8USP30PIK3CDBRD4CREBBP | |
| SCHEMBL20116365 | 0.80 | LRRK2 (0.46) | TBK1S1PR1HDAC4 | |
| SCHEMBL20676521 | 0.80 | PIK3CD (0.34) | MAPTKDM4EALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL20116456 | 0.80 | GBA1 (0.44) | KDM4EALDH1A1HDAC8S1PR1 | |
| SCHEMBL20676474 | 0.80 | USP30 (0.41) | KDM4EALDH1A1USP30PIK3CDBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |