SCHEMBL20117975

SCHEMBL20117975

NC(=O)c1ccc(-n2cccc2Cc2ccncc2)cc1NC1CCCCC1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSP90B1 P14625 2/20 0.60
KDM4E B2RXH2 1/20 0.40
TSHR P16473 1/20 0.40
HSP90AA1 P07900 16/20 0.40
HSP90AB1 P08238 2/20 0.40
JAK2 O60674 1/20 0.39
JAK1 P23458 1/20 0.39
TYK2 P29597 1/20 0.39
JAK3 P52333 1/20 0.39
TRAP1 Q12931 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA3 P07451 1/20 0.37
CA6 P23280 1/20 0.37
CA7 P43166 1/20 0.37
CA5B Q9Y2D0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20117974 0.92 HSP90B1 (0.71) HSP90B1HSP90AA1HSP90AB1
SCHEMBL20117732 0.91 HSP90B1 (0.65) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117980 0.90 HSP90B1 (0.57) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117738 0.90 HSP90B1 (0.63) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117688 0.89 HSP90B1 (0.60) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117729 0.89 HSP90B1 (0.60) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117787 0.85 HSP90B1 (0.60) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117958 0.83 HSP90B1 (0.49) HSP90B1HSP90AA1HSP90AB1JAK2JAK1
SCHEMBL20117976 0.83 HSP90B1 (0.60) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1
SCHEMBL20117692 0.83 HSP90B1 (0.59) HSP90B1KDM4ETSHRHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018081814-A1 GRP94 SELECTIVE INHIBITORS AND USES THEREOF UNIVERSITY OF KANSAS (US) 2018-05-03 WO disclosed