Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118064 | 1.00 | JAK2 (0.51) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL18208212 | 0.84 | JAK2 (0.52) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL18208215 | 0.84 | JAK2 (0.52) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL18208122 | 0.78 | KDM4E (0.50) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL18208125 | 0.78 | KDM4E (0.50) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL18208937 | 0.75 | TNKS (0.55) | TNKSKDM4EHSD17B10PKMHSD11B1 | |
| SCHEMBL18208934 | 0.75 | TNKS (0.55) | TNKSKDM4EHSD17B10PKMHSD11B1 | |
| SCHEMBL18208403 | 0.74 | IRAK4 (0.51) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL18208401 | 0.74 | IRAK4 (0.51) | JAK2JAK1TYK2JAK3TNKS | |
| SCHEMBL22947094 | 0.74 | KDM4E (0.67) | TNKSKDM4EHSD17B10HSD11B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |