Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.54 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | PLAT | P00750 | 3/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118281 | 0.78 | F2 (0.71) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL20118775 | 0.76 | F2 (0.63) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL2135316 | 0.70 | F2 (0.73) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7903320 | 0.70 | F2 (0.71) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL20118486 | 0.69 | CYP19A1 (0.40) | — | |
| SCHEMBL12545751 | 0.69 | F2 (0.65) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL29246859 | 0.68 | F2 (0.69) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL21336212 | 0.67 | HSD17B10 (0.60) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL20118630 | 0.67 | F2 (0.61) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL14599554 | 0.66 | PRSS1 (0.71) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |