Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 14/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17149052 | 0.84 | BACE1 (0.71) | BACE1BACE2 | |
| SCHEMBL20119536 | 0.80 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL20118942 | 0.79 | BACE1 (0.62) | BACE1BACE2USP30 | |
| SCHEMBL20119140 | 0.78 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL20119524 | 0.78 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL17149053 | 0.75 | BACE1 (0.72) | BACE1BACE2 | |
| SCHEMBL20119293 | 0.75 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL20119095 | 0.74 | BACE1 (0.49) | BACE1BACE2 | |
| SCHEMBL17149050 | 0.74 | BACE1 (0.70) | BACE1BACE2 | |
| SCHEMBL20119069 | 0.74 | BACE1 (0.52) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908824-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |