Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17149016 | 0.82 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL20056230 | 0.79 | BACE1 (0.63) | BACE1BACE2 | |
| SCHEMBL20118944 | 0.75 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL17149018 | 0.74 | BACE1 (0.69) | BACE1BACE2 | |
| SCHEMBL17149017 | 0.73 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL20119075 | 0.72 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL18567539 | 0.71 | BACE1 (0.64) | BACE1BACE2 | |
| SCHEMBL20056261 | 0.70 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL18567825 | 0.70 | BACE1 (0.61) | BACE1BACE2 | |
| SCHEMBL17149004 | 0.69 | BACE1 (0.67) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908824-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |