Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.49 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.49 |
| ▸ | FABP1 | P07148 | 9/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178765 | 0.86 | NR1H4 (0.48) | NR1H4HSD17B13FABP1FABP4 | |
| SCHEMBL20119181 | 0.83 | NR1H4 (0.55) | NR1H4HSD17B13FABP1FABP4 | |
| SCHEMBL20119278 | 0.82 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL20119237 | 0.80 | NR1H4 (0.49) | NR1H4HSD17B13 | |
| SCHEMBL20119257 | 0.78 | NR1H4 (0.44) | NR1H4HSD17B13 | |
| SCHEMBL20178809 | 0.76 | NR1H4 (0.48) | NR1H4HSD17B13FABP1FABP4 | |
| SCHEMBL20119266 | 0.75 | NR1H4 (0.44) | NR1H4 | |
| SCHEMBL20119236 | 0.75 | NR1H4 (0.49) | NR1H4FABP1 | |
| SCHEMBL20119766 | 0.75 | NR1H4 (0.60) | NR1H4 | |
| SCHEMBL20119313 | 0.75 | NR1H4 (0.46) | NR1H4FABP1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081285-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |