Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 9/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 9/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | INSR | P06213 | 2/20 | 0.32 |
| ▸ | LYN | P07948 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | ROS1 | P08922 | 2/20 | 0.32 |
| ▸ | FGR | P09769 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19466750 | 0.83 | AAK1 (0.62) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL15258059 | 0.83 | AAK1 (0.62) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19467007 | 0.80 | AAK1 (0.63) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19467280 | 0.80 | AAK1 (0.63) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19467009 | 0.80 | AAK1 (0.63) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19467282 | 0.80 | AAK1 (0.63) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19466875 | 0.79 | AAK1 (0.60) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19466877 | 0.79 | AAK1 (0.60) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL15254438 | 0.79 | AAK1 (0.48) | AAK1PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL19467247 | 0.79 | AAK1 (0.59) | AAK1PIM1DYRK3CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |