Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.50 |
| ▸ | HASPIN | Q8TF76 | 8/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122800 | 0.86 | DYRK1A (0.48) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL20122700 | 0.86 | DYRK1A (0.48) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL20122724 | 0.83 | DYRK1A (0.50) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL20123023 | 0.83 | DYRK1A (0.45) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL29756351 | 0.83 | DYRK1A (0.45) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL30664291 | 0.82 | DYRK1A (0.44) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL20123005 | 0.82 | DYRK1A (0.44) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL20122851 | 0.81 | DYRK1A (0.47) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL30664269 | 0.80 | KDM4E (0.45) | DYRK1AHASPINDYRK2AAK1ACHE | |
| SCHEMBL20122984 | 0.80 | DYRK1A (0.43) | DYRK1AHASPINDYRK2AAK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792262-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2021-03-17 | — | — | EP | disclosed |
| EP-3535263-B1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI SA (FR) | 2020-09-30 | — | — | EP | disclosed |
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |