Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756390 | 0.89 | PTGER4 (0.42) | PTGER4DYRK1ABRD4AAK1HASPIN | |
| SCHEMBL20122859 | 0.82 | PRKCI (0.42) | DYRK1AAAK1CCNT1CDK9 | |
| SCHEMBL30664212 | 0.82 | PRKCI (0.42) | DYRK1AAAK1CCNT1CDK9 | |
| SCHEMBL20123023 | 0.81 | DYRK1A (0.45) | DYRK1AAAK1HASPINDYRK2APOBEC3G | |
| SCHEMBL29756351 | 0.81 | DYRK1A (0.45) | DYRK1AAAK1HASPINDYRK2APOBEC3G | |
| SCHEMBL30664291 | 0.80 | DYRK1A (0.44) | DYRK1AAAK1HASPINDYRK2 | |
| SCHEMBL20123005 | 0.80 | DYRK1A (0.44) | DYRK1AAAK1HASPINDYRK2 | |
| SCHEMBL20122984 | 0.78 | DYRK1A (0.43) | DYRK1ABRD4AAK1HASPINDYRK2 | |
| SCHEMBL30664286 | 0.78 | DYRK1A (0.43) | DYRK1ABRD4AAK1HASPINDYRK2 | |
| SCHEMBL30664269 | 0.78 | KDM4E (0.45) | DYRK1AAAK1HASPINDYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |