Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721548 | 0.90 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL457993 | 0.84 | NPC1 (0.84) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL13162654 | 0.83 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL13162659 | 0.81 | NPC1 (0.97) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL13162641 | 0.81 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL13164090 | 0.81 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL23573548 | 0.80 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL8198182 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL23573547 | 0.80 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL13161968 | 0.80 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507230-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067272-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |