Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11960433 | 0.83 | EPHX2 (0.51) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL11954 | 0.80 | EPHX2 (0.59) | EPHX2NR1H4CA1CA2HDAC3 | |
| SCHEMBL11960431 | 0.77 | HDAC3 (0.56) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL15125586 | 0.76 | EPHX2 (0.55) | EPHX2NR1H4CA1CA2HDAC3 | |
| SCHEMBL11960454 | 0.75 | EPHX2 (0.45) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL11960442 | 0.75 | ANPEP (0.52) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL11774 | 0.75 | ANPEP (0.56) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL11960455 | 0.75 | BCHE (0.59) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL11960452 | 0.74 | ANPEP (0.51) | EPHX2NR1H4ANPEPERAP2CA1 | |
| SCHEMBL11981562 | 0.72 | ANPEP (0.49) | EPHX2NR1H4ANPEPERAP2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488532-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-05-09 | — | — | EP | disclosed |