Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19527797 | 0.86 | EGFR (0.47) | EGFRITKPTK2GRM4SYK | |
| SCHEMBL1943697 | 0.84 | PRKCQ (0.48) | EGFRITKSYK | |
| SCHEMBL1944490 | 0.83 | EGFR (0.41) | EGFRITKTBK1SYK | |
| SCHEMBL18995116 | 0.79 | MAPK8 (0.34) | EGFRITKJAK2SYK | |
| SCHEMBL15337213 | 0.79 | LRRK2 (0.34) | PTK2 | |
| SCHEMBL16072519 | 0.79 | EGFR (0.42) | EGFRITKTBK1SYK | |
| SCHEMBL15322084 | 0.79 | EGFR (0.42) | EGFRITKTBK1SYK | |
| SCHEMBL19731825 | 0.78 | EGFR (0.46) | EGFRITKSYK | |
| SCHEMBL18995054 | 0.78 | LRRK2 (0.39) | GRM4 | |
| SCHEMBL1944202 | 0.77 | RAF1 (0.40) | TBK1GRM4SYKIKBKEP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970275-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2018-05-09 | — | — | EP | disclosed |