Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | CDK11B | P21127 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626812 | 0.89 | PDGFRB (0.51) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL12336741 | 0.87 | PDGFRB (0.47) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL14949485 | 0.86 | PDGFRB (0.55) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL12336563 | 0.86 | PDGFRB (0.49) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL14949292 | 0.86 | PDGFRB (0.50) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL14949287 | 0.85 | PDGFRB (0.49) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL14949290 | 0.85 | PDGFRB (0.51) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL12336289 | 0.85 | PDGFRB (0.56) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL627644 | 0.84 | PDGFRB (0.50) | PDGFRBKITPDGFRACDK11BFLT3 | |
| SCHEMBL12348800 | 0.83 | PDGFRB (0.50) | PDGFRBKITPDGFRACDK11BFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550266-B1 | HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION | AMITECH THERAPEUTICS SOLUTIONS INC (US) | 2018-05-09 | — | — | EP | disclosed |