Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 15/20 | 0.83 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.83 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.72 |
| ▸ | EED | O75530 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | MLNR | O43193 | 1/20 | 0.68 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HLA-A | P04439 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desmetheylastemizole SCHEMBL29601510 | 0.91 | KCNH2 (1.00) | KCNH2NR4A2SSTR5EEDMEN1 | |
| SCHEMBL9580736 | 0.91 | SSTR5 (0.87) | KCNH2NR4A2SSTR5EEDMEN1 | |
| Desmetheylastemizole SCHEMBL1152697 | 0.91 | KCNH2 (1.00) | KCNH2NR4A2SSTR5EEDMEN1 | |
| Desmetheylastemizole SCHEMBL11473376 | 0.90 | KCNH2 (0.98) | KCNH2NR4A2SSTR5EEDMEN1 | |
| Desmetheylastemizole SCHEMBL11473379 | 0.90 | KCNH2 (0.98) | KCNH2NR4A2SSTR5EEDMEN1 | |
| SCHEMBL23696975 | 0.89 | KCNH2 (0.85) | KCNH2NR4A2SSTR5EEDMEN1 | |
| SCHEMBL13792457 | 0.87 | KCNH2 (0.77) | KCNH2NR4A2SSTR5EEDMEN1 | |
| SCHEMBL11381151 | 0.87 | SSTR5 (0.88) | KCNH2NR4A2SSTR5EEDMEN1 | |
| Bromide SCHEMBL8565771 | 0.85 | KCNH2 (0.69) | KCNH2NR4A2SSTR5EEDMEN1 | |
| Bromide SCHEMBL9698190 | 0.85 | KCNH2 (0.73) | KCNH2NR4A2SSTR5EEDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183209-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-20180215731-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183209-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | KCNH2 4867/4885NR4A2 1906/4885SSTR5 4672/4885 |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | KCNH2 4854/4885NR4A2 2889/4885SSTR5 4691/4885 |
| US-20180215731-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | KCNH2 4867/4885NR4A2 1906/4885SSTR5 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.