Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRB2 | P62993 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30057038 | 0.88 | SLC7A5 (0.51) | GRB2PTPN1SLC7A5PTGS1KDM4E | |
| SCHEMBL25186371 | 0.86 | GRIK1 (0.47) | GRB2PTPN1SLC7A5EPHX2PDE2A | |
| SCHEMBL25186372 | 0.86 | GRIK1 (0.47) | GRB2PTPN1SLC7A5EPHX2PDE2A | |
| SCHEMBL18893762 | 0.85 | GRB2 (0.52) | GRB2PTPN1SLC7A5PTGS1KDM4E | |
| SCHEMBL16163306 | 0.85 | GRB2 (0.52) | GRB2PTPN1SLC7A5PTGS1KDM4E | |
| SCHEMBL19929599 | 0.84 | SLC7A5 (0.54) | GRB2PTPN1SLC7A5PTGS1KDM4E | |
| SCHEMBL31177566 | 0.84 | EPHX2 (0.43) | PTPN1SLC7A5PTGS1EPHX2PDE2A | |
| Hydrochloric Acid SCHEMBL18893807 | 0.84 | PTPN1 (0.51) | GRB2PTPN1SLC7A5PTGS1KDM4E | |
| Hydrochloric Acid SCHEMBL18893793 | 0.84 | PTPN1 (0.51) | GRB2PTPN1SLC7A5PTGS1KDM4E | |
| SCHEMBL18174275 | 0.83 | EPHX2 (0.50) | EPHX2PPARGPDE2ALDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | EP300, HDAC3, HDAC1 | GRB2 421/4885PTPN1 2865/4885SLC7A5 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.