Sugi Predict

Sugi Predict / Compounds / SCHEMBL20133751

SCHEMBL20133751

SCHEMBL20133751

Cc1cc(C)c(C(=O)N2CCN(c3ccccc3C#N)CC2)cc1NC1CCN(c2ccccc2Cl)CC1

nearest known ligand 0.72

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 9/20 0.72
▸ RPTOR Q8N122 9/20 0.72
▸ MLST8 Q9BVC4 9/20 0.72
▸ ALDH1A1 P00352 1/20 0.44
▸ HSP90AA1 P07900 1/20 0.44
▸ GAA P10253 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ TACR3 P29371 1/20 0.43
▸ NAMPT P43490 1/20 0.43
▸ DCTPP1 Q9H773 1/20 0.42
▸ GRM5 P41594 1/20 0.41
▸ DRD2 P14416 2/20 0.41
▸ DRD4 P21917 2/20 0.41
▸ DRD3 P35462 2/20 0.41
▸ AVPR1A P37288 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20133739 0.95 MTOR (0.78) MTORRPTORMLST8ALDH1A1GAA
SCHEMBL20150218 0.93 MTOR (0.74) MTORRPTORMLST8GAAL3MBTL1
SCHEMBL22693146 0.92 MTOR (0.73) MTORRPTORMLST8GAAL3MBTL1
SCHEMBL21360385 0.91 MTOR (0.72) MTORRPTORMLST8ALDH1A1NAMPT
SCHEMBL20149902 0.91 MTOR (0.72) MTORRPTORMLST8ALDH1A1NAMPT
SCHEMBL20133691 0.90 MTOR (0.69) MTORRPTORMLST8ALDH1A1SMN1; SMN2
SCHEMBL22186814 0.90 MTOR (0.66) MTORRPTORMLST8ALDH1A1GAA
SCHEMBL21360383 0.89 MTOR (0.72) MTORRPTORMLST8ALDH1A1GAA
SCHEMBL20150031 0.89 MTOR (0.70) MTORRPTORMLST8NAMPT
SCHEMBL21360388 0.88 MTOR (0.85) MTORRPTORMLST8ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2018-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.