Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | KLK7 | P49862 | 6/20 | 0.33 |
| ▸ | TACR1 | P25103 | 5/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18109300 | 1.00 | ABCB1 (0.43) | ABCB1RORCKLK7TACR1KLK5 | |
| SCHEMBL18109299 | 1.00 | ABCB1 (0.43) | ABCB1RORCKLK7TACR1KLK5 | |
| SCHEMBL18109332 | 0.91 | ABCB1 (0.43) | ABCB1KLK7KLK5PRSS1PRSS2 | |
| SCHEMBL18109330 | 0.91 | ABCB1 (0.43) | ABCB1KLK7KLK5PRSS1PRSS2 | |
| SCHEMBL3717651 | 0.89 | ABCB1 (0.42) | ABCB1RORCKLK7KLK5PRSS1 | |
| SCHEMBL18109442 | 0.89 | ABCB1 (0.42) | ABCB1RORCKLK7TACR1KLK5 | |
| SCHEMBL18109438 | 0.89 | ABCB1 (0.42) | ABCB1RORCKLK7TACR1KLK5 | |
| SCHEMBL19461020 | 0.89 | ABCB1 (0.42) | ABCB1RORCKLK7TACR1KLK5 | |
| SCHEMBL895150 | 0.84 | ABCB1 (0.40) | ABCB1RORCKLK7NR1H2RXRA | |
| SCHEMBL895149 | 0.84 | ABCB1 (0.40) | ABCB1RORCKLK7NR1H2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |