Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20135829 | 0.82 | BRD4 (0.53) | BRD4HRH3PDE4B | |
| SCHEMBL15553164 | 0.78 | BRD4 (0.54) | BRD4HRH3PDE4B | |
| SCHEMBL19638559 | 0.77 | BRD4 (0.67) | BRD4 | |
| SCHEMBL15551649 | 0.75 | BRD4 (0.53) | BRD4HRH3PDE4B | |
| SCHEMBL20135831 | 0.74 | BRD4 (0.61) | BRD4 | |
| SCHEMBL15552656 | 0.74 | BRD4 (0.55) | BRD4HRH3 | |
| SCHEMBL28029408 | 0.71 | BRD4 (0.51) | BRD4HRH3 | |
| SCHEMBL28029767 | 0.70 | BRD4 (0.53) | BRD4HRH3 | |
| SCHEMBL20135826 | 0.68 | BRD4 (0.49) | BRD4 | |
| SCHEMBL19638611 | 0.67 | BRD4 (0.72) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858990-B1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC (US) | 2018-05-16 | — | — | EP | claimed |