Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 12/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | BRAF | P15056 | 3/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.76 |
| ▸ | RAF1 | P04049 | 2/20 | 0.76 |
| ▸ | KDR | P35968 | 2/20 | 0.76 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.76 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.76 |
| ▸ | NEK2 | P51955 | 2/20 | 0.76 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.76 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.76 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.76 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.76 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.76 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.76 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | EGFR | P00533 | 1/20 | 0.76 |
| ▸ | KRAS | P01116 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018733 | 0.93 | CYP2C19 (0.81) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL2162861 | 0.91 | CYP2C19 (0.78) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL20400626 | 0.89 | CYP2C9 (0.86) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL29898567 | 0.88 | CYP2C19 (0.79) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL27101426 | 0.88 | CYP2C19 (0.79) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL2162921 | 0.88 | CYP2C19 (0.77) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL2163092 | 0.88 | CYP2C19 (0.79) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL10246457 | 0.87 | CYP2C19 (0.84) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL299487 | 0.87 | CYP2C19 (1.00) | CYP2C19CYP2D6BRAFRIPK2RAF1 | |
| SCHEMBL298927 | 0.87 | BRAF (0.89) | CYP2C19CYP2D6BRAFRIPK2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440969-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440969-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150080372-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2015-03-19 | — | — | US | disclosed |
| US-20150080372-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2015-03-19 | — | — | US | disclosed |
| US-20110183988-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2011-07-28 | — | — | US | disclosed |
| US-20110183988-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2011-07-28 | — | — | US | disclosed |
| US-20110183988-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2011-07-28 | — | — | US | disclosed |
| WO-2011079133-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079133-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183988-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | BRAF, ARAF, NRAS | CYP2C19 2453/4885CYP2D6 2058/4885BRAF 1/4885 |
| US-20150080372-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | BRAF, ARAF, NRAS | CYP2C19 2453/4885CYP2D6 2058/4885BRAF 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.