Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.67 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013242 | 0.91 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2015950 | 0.91 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL6918071 | 0.90 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2013516 | 0.90 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2013098 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2013804 | 0.85 | HCRTR1 (0.73) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2015002 | 0.85 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9ADRD3 | |
| SCHEMBL2017845 | 0.85 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2014120 | 0.85 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2017387 | 0.85 | HCRTR1 (0.71) | HCRTR1HCRTR2NPC1RAB9AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |