Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.92 |
| ▸ | ATM | Q13315 | 18/20 | 0.92 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.92 |
| ▸ | ATR | Q13535 | 6/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17272531 | 0.96 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17242634 | 0.96 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17272494 | 0.96 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17272507 | 0.92 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17242594 | 0.92 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17272544 | 0.92 | MTOR (0.92) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17242644 | 0.91 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17272483 | 0.91 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17242482 | 0.91 | ATM (1.00) | MTORATMPIK3CAATRKCNH2 | |
| SCHEMBL17242505 | 0.91 | ATM (1.00) | MTORATMPIK3CAATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185468-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA UK LIMITED (GB) | 2019-06-20 | — | — | US | disclosed |
| US-10189834-B2 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer | ASTRAZENECA AB (SE) | 2019-01-29 | — | — | US | disclosed |
| US-20180134699-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA UK LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134699-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, CHEK2, CHEK1 | MTOR 393/4885ATM 1/4885PIK3CA 229/4885 |
| US-20190185468-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, CHEK2, CHEK1 | MTOR 393/4885ATM 1/4885PIK3CA 229/4885 |
| US-10189834-B2 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer | ATM, CHEK2, CHEK1 | MTOR 393/4885ATM 1/4885PIK3CA 229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.