Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 4/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138806 | 1.00 | GSK3A (0.48) | GSK3AGSK3BIRAK4TGFBR1PIM1 | |
| SCHEMBL20138847 | 0.83 | GSK3A (0.56) | GSK3AGSK3B | |
| SCHEMBL20138846 | 0.83 | GSK3A (0.56) | GSK3AGSK3B | |
| SCHEMBL20138984 | 0.83 | HPGD (0.47) | IRAK4 | |
| SCHEMBL20138986 | 0.83 | HPGD (0.47) | IRAK4 | |
| SCHEMBL18208170 | 0.77 | GSK3B (0.58) | GSK3AGSK3BABL1 | |
| SCHEMBL18208167 | 0.77 | GSK3B (0.58) | GSK3AGSK3BABL1 | |
| SCHEMBL20138815 | 0.76 | GSK3A (0.51) | GSK3AGSK3BPIM1ABL1 | |
| SCHEMBL20138814 | 0.76 | GSK3A (0.51) | GSK3AGSK3BPIM1ABL1 | |
| SCHEMBL20142928 | 0.76 | GSK3B (0.58) | GSK3AGSK3BABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |