Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.69 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.69 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.69 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139235 | 1.00 | MTOR (0.69) | MTORRPTORMLST8SLC6A7CHRM4 | |
| SCHEMBL20158934 | 0.92 | MTOR (0.69) | MTORRPTORMLST8SLC6A7CHRM4 | |
| SCHEMBL20139615 | 0.92 | MTOR (0.69) | MTORRPTORMLST8SLC6A7CHRM4 | |
| SCHEMBL20158922 | 0.88 | MTOR (0.64) | MTORRPTORMLST8CHRM4KDM4E | |
| SCHEMBL20141650 | 0.86 | MTOR (0.71) | MTORRPTORMLST8CHRM4KDM4E | |
| SCHEMBL20141653 | 0.86 | MTOR (0.71) | MTORRPTORMLST8CHRM4KDM4E | |
| SCHEMBL20159030 | 0.86 | MTOR (0.62) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20141139 | 0.85 | MTOR (0.72) | MTORRPTORMLST8CHRM4KDM4E | |
| SCHEMBL20159013 | 0.85 | MTOR (0.80) | MTORRPTORMLST8CHRM4KDM4E | |
| SCHEMBL20141137 | 0.85 | MTOR (0.72) | MTORRPTORMLST8CHRM4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |