Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139564 | 1.00 | MTOR (0.52) | MTORRPTORMLST8CHRM4HTR7 | |
| SCHEMBL20139324 | 1.00 | MTOR (0.52) | MTORRPTORMLST8CHRM4HTR7 | |
| SCHEMBL20140804 | 0.91 | MTOR (0.53) | MTORRPTORMLST8CHRM4HTR7 | |
| SCHEMBL20140802 | 0.91 | MTOR (0.53) | MTORRPTORMLST8CHRM4HTR7 | |
| SCHEMBL20139300 | 0.91 | CHRM4 (0.58) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20139298 | 0.91 | CHRM4 (0.58) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20141802 | 0.90 | MTOR (0.54) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20141803 | 0.90 | MTOR (0.54) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20159120 | 0.89 | MTOR (0.55) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20159162 | 0.89 | MTOR (0.47) | MTORRPTORMLST8CHRM4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |