Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139998 | 0.90 | DRD4 (0.40) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157267 | 0.84 | DRD4 (0.52) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20140542 | 0.81 | DRD4 (0.50) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20140513 | 0.80 | DRD4 (0.41) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20157462 | 0.78 | KDM4E (0.40) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20156945 | 0.78 | MTOR (0.37) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20140043 | 0.77 | CHRM2 (0.46) | ALDH1A1LMNAMTORRPTORMLST8 | |
| SCHEMBL20139884 | 0.77 | BDKRB1 (0.47) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20129604 | 0.75 | MTOR (0.47) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL20140126 | 0.73 | MTOR (0.53) | DRD4DRD3DRD2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |