Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.76 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.76 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20143031 | 1.00 | MTOR (0.76) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20140335 | 0.89 | MTOR (0.59) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20140338 | 0.89 | MTOR (0.59) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20140568 | 0.87 | MTOR (0.58) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20140565 | 0.87 | MTOR (0.58) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20139537 | 0.86 | MTOR (1.00) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20139536 | 0.86 | MTOR (1.00) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20159120 | 0.85 | MTOR (0.55) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20139300 | 0.85 | CHRM4 (0.58) | MTORRPTORMLST8CHRM2CHRM5 | |
| SCHEMBL20139298 | 0.85 | CHRM4 (0.58) | MTORRPTORMLST8CHRM2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |