Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK1 | P23458 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 4/20 | 0.50 |
| ▸ | BTK | Q06187 | 4/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29538618 | 0.90 | JAK1 (0.59) | EGFRJAK2JAK1JAK3BTK | |
| SCHEMBL20139429 | 0.90 | JAK1 (0.59) | EGFRJAK2JAK1JAK3BTK | |
| SCHEMBL20139063 | 0.87 | JAK1 (0.57) | EGFRJAK2JAK1JAK3BTK | |
| SCHEMBL20150991 | 0.85 | EGFR (0.53) | EGFRJAK2JAK1JAK3BTK | |
| SCHEMBL20138988 | 0.84 | EGFR (0.60) | EGFRJAK3BTKPIK3CDCSF1R | |
| SCHEMBL21484316 | 0.84 | EGFR (0.50) | EGFRJAK2JAK1JAK3BTK | |
| SCHEMBL20143667 | 0.82 | PIK3CD (0.56) | EGFRJAK3BTKPIK3CDCSF1R | |
| SCHEMBL20150470 | 0.82 | EGFR (0.57) | EGFRJAK2JAK3BTKCSF1R | |
| SCHEMBL21484334 | 0.81 | ERBB2 (0.62) | EGFRJAK2JAK3SRC | |
| SCHEMBL20139025 | 0.81 | CSF1R (0.56) | EGFRJAK3BTKPIK3CDCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018088780-A1 | NOVEL PYRROLOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-05-17 | — | — | WO | disclosed |