SCHEMBL20140533 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	CHRM2	P08172	4/20	0.46

▸	MAPT	P10636	4/20	0.40

▸	MTOR	P42345	2/20	0.39

▸	RPTOR	Q8N122	2/20	0.39

▸	MLST8	Q9BVC4	2/20	0.39

▸	EGLN1	Q9GZT9	1/20	0.37

▸	ALDH1A1	P00352	4/20	0.36

▸	LMNA	P02545	1/20	0.36

▸	GRM1	Q13255	1/20	0.36

▸	CHRM4	P08173	4/20	0.35

▸	CHRM1	P11229	3/20	0.34

▸	CHRM5	P08912	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20157101	1.00	CHRM2 (0.46)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20139953	0.86	CHRM2 (0.46)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20140022	0.83	CHRM2 (0.49)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20140800	0.83	CHRM2 (0.53)	CHRM2MTORRPTORMLST8GRM1
SCHEMBL20139926	0.82	CHRM2 (0.50)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20140314	0.82	CHRM2 (0.43)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20140583	0.82	CHRM2 (0.43)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20140043	0.81	CHRM2 (0.46)	CHRM2MAPTMTORRPTORMLST8
SCHEMBL20140905	0.81	CHRM2 (0.51)	CHRM2MTORRPTORMLST8GRM1
SCHEMBL20140908	0.81	CHRM2 (0.51)	CHRM2MTORRPTORMLST8GRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018089433-A1	PHENYL mTORC INHIBITORS AND USES THEREOF	NAVITOR PHARMACEUTICALS, INC. (US)	2018-05-17	—	—	WO	disclosed