Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.78 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.78 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139236 | 0.93 | MTOR (0.68) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20140500 | 0.92 | MTOR (0.67) | MTORRPTORMLST8HTR7KDM4E | |
| SCHEMBL20159067 | 0.91 | MTOR (0.65) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20140543 | 0.90 | MTOR (0.65) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20139877 | 0.89 | MTOR (0.64) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20140534 | 0.89 | MTOR (0.63) | MTORRPTORMLST8HTR7HTT | |
| SCHEMBL20159289 | 0.89 | MTOR (0.63) | MTORRPTORMLST8HTR7HTT | |
| SCHEMBL20159141 | 0.89 | MTOR (0.64) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20139283 | 0.89 | MTOR (0.63) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20141905 | 0.89 | MTOR (0.63) | MTORRPTORMLST8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |